The second season of the crime drama centers on Tony's increasing suspision of one of his closest friends Big Pussy Bonpensiero, who is actually an FBI informant while dealing with his returning panic attacks. Meanwhile, conflicts within the family continue raising as Tony's sister Janice also returns to New Jersey. Her daughter Meadow is about to go to college, but her personal life intersects with Tony's crime life for the first time. Former boss Jackie Aprile's brother Richie is set free from jail takes vengeful actions toward Tony and his business.