When a case of lab rats are carried on the flight TS Air 318 from Los Angeles to Kansas City and one of them suddenly bites passenger Ralph, the plane harshly attacked by a mysterious virus. As the disease begins to spread, innocent passengers rapidly turn into savagely and bloodthirsty killers. Forced to touch down at an abandoned terminal and placed under quarantine, the increasingly hopeless crew and passengers now must stand together to survive the quarantine.