Machete Cortez and his beloved partner Sartana Rivera are stopping the crimes themselves, when an unknown group intervenes and kills Sartana. Machete is arrested by a corrupt officer, accused of killing his beloved but the President of the USA Rathcock crosses the path, Machete is brought to White House where he is offered to become US citizenship if he accepts a seemlingy impossible mission - eliminating Marcos Mendez, a psychopath who is threatening to fire a nuclear missile at Washington, D.C.